103 research outputs found
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Evaluating the impact of video-based versus traditional lectures on student learning
Copyright ©2010 International Research Journals. This full-text open access article is available at the link below.Although, computer assisted learning and multimedia programs have emerged into higher education institutions, there is no clear evidence that such a movement can improve student learning. This study was conducted to provide an objective assessment of the impact of lectures with the use of video clips on student learning over traditional teaching methods. Five university students participated and experimental control was achieved using an alternating-treatments design. Overall, students experienced sixteen 5-minute lectures, half on kinesiology and half on psychological issues for children, delivered by either traditional or video-based methods. Results showed that teaching material based on video clips was at least as equally effective as standard teaching lectures. Similar data were collected during 1-, 2-, and 3-week follow-up measures. These results come in agreement with the current literature reinforcing the suggestion that the use of videos in education may hold great promises.This article is available through the Brunel Open Access Publishing Fund
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Generalized effects of video modeling on establishing instructional stimulus control in children with autism: Results of a preliminary study
Video modeling has been suggested as a powerful treatment tool that has concentrated on increasing a variety of skills in children with autism. However, it has rarely been examined as a behavioral procedure for eliminating kinds of behaviors (e.g., noncompliance), a target that is often included in children’s support plans. The present study provides preliminary effects of video modeling on establishing instructional stimulus control over a simple behavior (cleaning up a toy) that required the termination of an ongoing activity. Three children with autism participated, and experimental control was accomplished using a multiple-baseline-across-subjects design. The results showed that this procedure can be effective for children with lower baseline levels of disruptive behaviors and more developed imitation skills. Successful responding generalized across stimuli and subjects and was maintained at a 1-month follow-up assessment. Specific guidelines for building
video modeling into real teaching situations are also discussed
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Teaching complex social skills to children with autism; advances of video modeling
Although there has been a corresponding explosion of literature regarding the treatment
of the social deficits in autism, the establishment of more complex social behaviors still
remains a challenge. Video modeling appears as one approach to have the potential to
successfully address this challenge. Following an introduction to modeling that
constitutes the basis of this procedure, the current paper explores those video modeling
studies that have targeted the promotion of complex social skills. It is suggested that this
approach could be an effective addition to peer-mediated treatment procedures, especially
for children with autism who cannot always be in environments where peers are present.
Further, the likely success of video modeling seems to be dependent upon the prior
elimination of behaviors that interfere with the development of imitation skills
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Use of video modeling to increase generalization of social play by children with autism
The use of video modeling to increase generalization of social play skills in children with autism is discussed. The possible reasons that have made this procedure so favorable among researchers and practitioners are explored. Two studies are described in which video modeling increased the generalization of social play in 6 children, and critical features of procedure are emphasized. Suggestions regarding the potential mechanisms responsible for the effectiveness of this procedure are discussed relative to basic behavioral theory and research
Identification of two novel mutations in CDHR1 in consanguineous Spanish families with autosomal recessive retinal dystrophy.
Inherited retinal dystrophies present extensive phenotypic and genetic heterogeneity, posing a challenge for patients' molecular and clinical diagnoses. In this study, we wanted to clinically characterize and investigate the molecular etiology of an atypical form of autosomal recessive retinal dystrophy in two consanguineous Spanish families. Affected members of the respective families exhibited an array of clinical features including reduced visual acuity, photophobia, defective color vision, reduced or absent ERG responses, macular atrophy and pigmentary deposits in the peripheral retina. Genetic investigation included autozygosity mapping coupled with exome sequencing in the first family, whereas autozygome-guided candidate gene screening was performed by means of Sanger DNA sequencing in the second family. Our approach revealed nucleotide changes in CDHR1; a homozygous missense variant (c.1720C > G, p.P574A) and a homozygous single base transition (c.1485 + 2T > C) affecting the canonical 5' splice site of intron 13, respectively. Both changes co-segregated with the disease and were absent among cohorts of unrelated control individuals. To date, only five mutations in CDHR1 have been identified, all resulting in premature stop codons leading to mRNA nonsense mediated decay. Our work reports two previously unidentified homozygous mutations in CDHR1 further expanding the mutational spectrum of this gene
Field-induced breakdown of the quantum Hall effect
A numerical analysis is made of the breakdown of the quantum Hall effect
caused by the Hall electric field in competition with disorder. It turns out
that in the regime of dense impurities, in particular, the number of localized
states decreases exponentially with the Hall field, with its dependence on the
magnetic and electric field summarized in a simple scaling law. The physical
picture underlying the scaling law is clarified. This intra-subband process,
the competition of the Hall field with disorder, leads to critical breakdown
fields of magnitude of a few hundred V/cm, consistent with observations, and
accounts for their magnetic-field dependence \propto B^{3/2} observed
experimentally. Some testable consequences of the scaling law are discussed.Comment: 7 pages, Revtex, 3 figures, to appear in Phys. Rev.
Homozygosity mapping reveals novel and known mutations in Pakistani families with inherited retinal dystrophies.
Inherited retinal dystrophies are phenotypically and genetically heterogeneous. This extensive heterogeneity poses a challenge when performing molecular diagnosis of patients, especially in developing countries. In this study, we applied homozygosity mapping as a tool to reduce the complexity given by genetic heterogeneity and identify disease-causing variants in consanguineous Pakistani pedigrees. DNA samples from eight families with autosomal recessive retinal dystrophies were subjected to genome wide homozygosity mapping (seven by SNP arrays and one by STR markers) and genes comprised within the detected homozygous regions were analyzed by Sanger sequencing. All families displayed consistent autozygous genomic regions. Sequence analysis of candidate genes identified four previously-reported mutations in CNGB3, CNGA3, RHO, and PDE6A, as well as three novel mutations: c.2656C > T (p.L886F) in RPGRIP1, c.991G > C (p.G331R) in CNGA3, and c.413-1G > A (IVS6-1G > A) in CNGB1. This latter mutation impacted pre-mRNA splicing of CNGB1 by creating a -1 frameshift leading to a premature termination codon. In addition to better delineating the genetic landscape of inherited retinal dystrophies in Pakistan, our data confirm that combining homozygosity mapping and candidate gene sequencing is a powerful approach for mutation identification in populations where consanguineous unions are common
Using video modeling to teach complex social sequences to children with autism
This study comprised of two experiments was designed to teach complex social sequences to children with autism. Experimental control was achieved by collecting data using means of within-system design methodology. Across a number of conditions children were taken to a room to view one of the four short videos of two people engaging in a simple sequence of activities. Then, each child’s behavior was assessed in the same room. Results showed that this video modeling procedure enhanced the social initiation skills of all children. It also facilitated reciprocal play engagement and imitative responding of a sequence of behaviors, in which social initiation was not included. These behavior changes generalized across peers and maintained after a 1- and 2-month follow-up period
Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination.
Inherited retinal dystrophies (iRDs) are a group of genetically and clinically heterogeneous conditions resulting from mutations in over 250 genes. Here, homozygosity mapping and whole-exome sequencing (WES) in a consanguineous family revealed a homozygous missense mutation, c.973C>T (p.His325Tyr), in RCBTB1. In affected individuals, it was found to segregate with retinitis pigmentosa (RP), goiter, primary ovarian insufficiency, and mild intellectual disability. Subsequent analysis of WES data in different cohorts uncovered four additional homozygous missense mutations in five unrelated families in whom iRD segregates with or without syndromic features. Ocular phenotypes ranged from typical RP starting in the second decade to chorioretinal dystrophy with a later age of onset. The five missense mutations affect highly conserved residues either in the sixth repeat of the RCC1 domain or in the BTB1 domain. A founder haplotype was identified for mutation c.919G>A (p.Val307Met), occurring in two families of Mediterranean origin. We showed ubiquitous mRNA expression of RCBTB1 and demonstrated predominant RCBTB1 localization in human inner retina. RCBTB1 was very recently shown to be involved in ubiquitination, more specifically as a CUL3 substrate adaptor. Therefore, the effect on different components of the CUL3 and NFE2L2 (NRF2) pathway was assessed in affected individuals' lymphocytes, revealing decreased mRNA expression of NFE2L2 and several NFE2L2 target genes. In conclusion, our study puts forward mutations in RCBTB1 as a cause of autosomal-recessive non-syndromic and syndromic iRD. Finally, our data support a role for impaired ubiquitination in the pathogenetic mechanism of RCBTB1 mutations
Exome sequencing: the sweet spot before whole genomes
The development of massively parallel sequencing technologies, coupled with new massively parallel DNA enrichment technologies (genomic capture), has allowed the sequencing of targeted regions of the human genome in rapidly increasing numbers of samples. Genomic capture can target specific areas in the genome, including genes of interest and linkage regions, but this limits the study to what is already known. Exome capture allows an unbiased investigation of the complete protein-coding regions in the genome. Researchers can use exome capture to focus on a critical part of the human genome, allowing larger numbers of samples than are currently practical with whole-genome sequencing. In this review, we briefly describe some of the methodologies currently used for genomic and exome capture and highlight recent applications of this technology
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